This monoclonal antibody reacts with VSV-M protein.
Highlights:
- Reacts with VSV-M protein
- Suitable for Western Blot applications
Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.
Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.
Product Type: | Antibody |
Name: | Anti-VSV-M [23H12] |
Antigen: | VSV-M |
Accession ID: | P03519 |
Host: | Mouse |
Isotype: | IgG2a kappa |
Clonality: | Monoclonal |
Clone Name: | 23H12 |
Specificity: | VSV-Ind matrix (M) protein |
Reactivity: | Human |
Immunogen: | VSV infection |
Format: | Liquid |
Purification Method: | Protein G purified |
Buffer: | PBS, 0.05% (w/v) Sodium Azide |
Tested Applications: | Western blot (1:1000) |
Concentration: | 1mg/mL |
Amount: | 100uL |
Storage: | -20C (avoid repeated freeze / thaw cycles) |
Shipped: | Cold packs |
From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.
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